TL;DR No hacks or patches required 1-minute 1-day way to make it work.

There are a lot of guides about Rocksmith and No Cable Mode both for Windows and Mac but not for Roland Quad-Capture. I don’t know actually why but the basic flow is:

1. Start Audio MIDI Setup
2. Go to Audio Devices
3. Click + on the bottom, choose “Create Aggregate Device”
4. Rename your new device to “Rocksmith USB Guitar Adapter”

It didn’t work for me. So, I tried to find another way. I found an app named Loopback - usually, people used it to combine mic with audio sources or combine multiple input devices into a single virtual device. I used it the other way. I’ve created a virtual device with Rocksmith USB Guitar Adapter name where added Roland Quad-Capture Left channel as an output for this virtual device. After that my higher-quality audio interface works as the input instead of the RealTone cable.

Also, I’ve changed Rocksmith.ini file a little bit:

[Audio]
EnableMicrophone=1
ExclusiveMode=0
LatencyBuffer=4
ForceDefaultPlaybackDevice=1
ForceWDM=0
ForceDirectXSink=0
Win32UltraLowLatencyMode=1
DumpAudioLog=0
MaxOutputBufferSize=0
[Renderer.MacOS]
ScreenWidth=0
ScreenHeight=0
Fullscreen=2
VisualQuality=1
RenderingWidth=0
RenderingHeight=0
EnablePostEffects=1
EnableShadows=1
EnableHighResScope=1
EnableDepthOfField=1
EnablePerPixelLighting=1
MsaaSamples=4
DisableBrowser=0
[Net]
UseProxy=1
[Global]
Version=1